Apoptotic Signaling Activated by Modulation of the F(0)F(1)-ATPase: Implications for Selective Killing of Autoimmune Lymphocytes

7-Chloro-5-(4-hydroxyphenyl)-1-methyl-3-(napthalen-2-ylmetyl)-4,5,-dihydro-1H-benzo[b][1,4]diazepin-2(3H)-one (Bz-423) is a proapoptotic 1,4-benzodiazepine that potently suppresses disease in the murine model of lupus by selectively killing pathogenic lymphocytes. In MRL/MpJ-Fas(lpr) (MRL-lpr) mice,...

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Detalhes bibliográficos
Main Authors: Sundberg, Thomas B., Swenson, Lara, Wahl, Daniel R., Opipari, Anthony W., Glick, Gary D.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2009
Assuntos:
Inflammation, Immunopharmacology, and Asthma
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775264/
https://ncbi.nlm.nih.gov/pubmed/19706792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.156422
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