Anxiolytic Effects of Phosphodiesterase-2 Inhibitors Associated with Increased cGMP Signaling

Phosphodiesterase (PDE)-2 is a component of the nitric-oxide synthase (NOS)/guanylyl cyclase signaling pathway in the brain. Given recent evidence that pharmacologically induced changes in NO-cGMP signaling can affect anxiety-related behaviors, the effects of the PDE2 inhibitors (2-(3,4-dimethoxyben...

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Autors principals: Masood, Anbrin, Huang, Ying, Hajjhussein, Hassan, Xiao, Lan, Li, Hao, Wang, Wei, Hamza, Adel, Zhan, Chang-Guo, O'Donnell, James M.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2009
Matèries:
Behavioral Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775258/
https://ncbi.nlm.nih.gov/pubmed/19684253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.156729
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