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Cofactor binding and enzymatic activity in an unevolved superfamily of de novo designed 4-helix bundle proteins
To probe the potential for enzymatic activity in unevolved amino acid sequence space, we created a combinatorial library of de novo 4-helix bundle proteins. This collection of novel proteins can be considered an “artificial superfamily” of helical bundles. The superfamily of 102-residue proteins was...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Wiley Subscription Services, Inc., A Wiley Company
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2775209/ https://ncbi.nlm.nih.gov/pubmed/19544578 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.147 |
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