RelA/p65 functions to maintain cellular senescence by regulating genomic stability and DNA repair

Nuclear factor (NF)-κB is a positive regulator of tumour development and progression, but how it functions in normal cells leading to oncogenesis is not clear. As cellular senescence has proven to be an intrinsic tumour suppressor mechanism that cells must overcome to establish deregulated growth, w...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Wang, Jingxin, Jacob, Naduparambil K, Ladner, Katherine J, Beg, Amer, Perko, James D, Tanner, Stephan M, Liyanarachchi, Sandya, Fishel, Richard, Guttridge, Denis C
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2009
Schlagworte:
Scientific Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775178/
https://ncbi.nlm.nih.gov/pubmed/19779484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2009.197
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