RelA/p65 functions to maintain cellular senescence by regulating genomic stability and DNA repair

Nuclear factor (NF)-κB is a positive regulator of tumour development and progression, but how it functions in normal cells leading to oncogenesis is not clear. As cellular senescence has proven to be an intrinsic tumour suppressor mechanism that cells must overcome to establish deregulated growth, w...

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Detalhes bibliográficos
Main Authors: Wang, Jingxin, Jacob, Naduparambil K, Ladner, Katherine J, Beg, Amer, Perko, James D, Tanner, Stephan M, Liyanarachchi, Sandya, Fishel, Richard, Guttridge, Denis C
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
Assuntos:
Scientific Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775178/
https://ncbi.nlm.nih.gov/pubmed/19779484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2009.197
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