Degradation of Promoter-bound p65/RelA Is Essential for the Prompt Termination of the Nuclear Factor κB Response

Transcription factors of the nuclear factor (NF)-κB/Rel family translocate into the nucleus upon degradation of the IκBs. Postinduction repression of NF-κB activity depends on NF-κB–regulated resynthesis of IκBα, which dissociates NF-κB from DNA and exports it to the cytosol. We found that after act...

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Bibliographic Details
Main Authors: Saccani, Simona, Marazzi, Ivan, Beg, Amer A., Natoli, Gioacchino
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2004
Subjects:
Brief Definitive Report
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2213320/
https://ncbi.nlm.nih.gov/pubmed/15226358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20040196
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