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Tetraspanin12 regulates ADAM10-dependent cleavage of amyloid precursor protein

Using mass spectrometry, we identified ADAM10 (a membrane-associated metalloproteinase) as a partner for TSPAN12, a tetraspanin protein. TSPAN12-ADAM10 interaction was confirmed by reciprocal coimmunoprecipitation in multiple tumor cell lines. TSPAN12, to a greater extent than other tetraspanins (CD...

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Hlavní autoři: Xu, Daosong, Sharma, Chandan, Hemler, Martin E.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Federation of American Societies for Experimental Biology 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775005/
https://ncbi.nlm.nih.gov/pubmed/19587294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.09-133462
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