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TspanC8 tetraspanins differentially regulate the cleavage of ADAM10 substrates, Notch activation and ADAM10 membrane compartmentalization

The metalloprotease ADAM10 mediates the shedding of the ectodomain of various cell membrane proteins, including APP, the precursor of the amyloid peptide Aβ, and Notch receptors following ligand binding. ADAM10 associates with the members of an evolutionary conserved subgroup of tetraspanins, referr...

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Detalhes bibliográficos
Publicado no:Cell Mol Life Sci
Main Authors: Jouannet, Stéphanie, Saint-Pol, Julien, Fernandez, Laurent, Nguyen, Viet, Charrin, Stéphanie, Boucheix, Claude, Brou, Christel, Milhiet, Pierre-Emmanuel, Rubinstein, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4819958/
https://ncbi.nlm.nih.gov/pubmed/26686862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-015-2111-z
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