TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammals

The metalloprotease ADAM10/Kuzbanian catalyzes the ligand-dependent ectodomain shedding of Notch receptors and activates Notch. Here, we show that the human tetraspanins of the evolutionary conserved TspanC8 subfamily (Tspan5, Tspan10, Tspan14, Tspan15, Tspan17, and Tspan33) directly interact with A...

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Detalhes bibliográficos
Main Authors: Dornier, Emmanuel, Coumailleau, Franck, Ottavi, Jean-François, Moretti, Julien, Boucheix, Claude, Mauduit, Philippe, Schweisguth, François, Rubinstein, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2012
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3483123/
https://ncbi.nlm.nih.gov/pubmed/23091066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201201133
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