Uptake/Efflux Transport of Tramadol Enantiomers and O-Desmethyl-Tramadol: Focus on P-Glycoprotein

ABSTRACT: The analgesic effect of tramadol (TMD) results from the monoaminergic effect of its two enantiomers, (+)-TMD and (−)-TMD as well as its opioid metabolite (+)-O-desmethyl-tramadol (M1). P-glycoprotein (P-gp) might be of importance in the analgesic and tolerability profile variability of TMD...

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Hlavní autoři: Kanaan, Mouna, Daali, Youssef, Dayer, Pierre, Desmeules, Jules
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Publishing Ltd 2009
Témata:
Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2774482/
https://ncbi.nlm.nih.gov/pubmed/19496778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1742-7843.2009.00428.x
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