[(11)C]Flumazenil brain uptake is influenced by the blood-brain barrier efflux transporter P-glycoprotein

BACKGROUND: [(11)C]Flumazenil and positron emission tomography (PET) are used clinically to assess gamma-aminobutyric acid (GABA)-ergic function and to localize epileptic foci prior to resective surgery. Enhanced P-glycoprotein (P-gp) activity has been reported in epilepsy and this may confound inte...

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Detalhes bibliográficos
Main Authors: Froklage, Femke E, Syvänen, Stina, Hendrikse, N Harry, Huisman, Marc C, Molthoff, Carla FM, Tagawa, Yoshihiko, Reijneveld, Jaap C, Heimans, Jan J, Lammertsma, Adriaan A, Eriksson, Jonas, de Lange, Elizabeth CM, Voskuyl, Rob A
Formato: Artigo
Idioma:Inglês
Publicado em: Springer 2012
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3348032/
https://ncbi.nlm.nih.gov/pubmed/22455873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2191-219X-2-12
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