Altered GABA(A) receptor density and unaltered blood–brain barrier [(11)C]flumazenil transport in drug-resistant epilepsy patients with mesial temporal sclerosis

Studies in rodents suggest that flumazenil is a P-glycoprotein substrate at the blood–brain barrier. This study aimed to assess whether [(11)C]flumazenil is a P-glycoprotein substrate in humans and to what extent increased P-glycoprotein function in epilepsy may confound interpretation of clinical [...

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Detalhes bibliográficos
Publicado no:J Cereb Blood Flow Metab
Main Authors: Froklage, Femke E, Postnov, Andrey, Yaqub, Maqsood M, Bakker, Esther, Boellaard, Ronald, Hendrikse, N Harry, Comans, Emile FI, Schuit, Robert C, Schober, Patrick, Velis, Demetrios N, Zwemmer, Jack, Heimans, Jan J, Lammertsma, Adriaan A, Voskuyl, Rob A, Reijneveld, Jaap C
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2015
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5167109/
https://ncbi.nlm.nih.gov/pubmed/26661244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0271678X15618219
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