(R)-[(11)C]Verapamil PET studies to assess changes in P-glycoprotein expression and functionality in rat blood-brain barrier after exposure to kainate-induced status epilepticus

BACKGROUND: Increased functionality of efflux transporters at the blood-brain barrier may contribute to decreased drug concentrations at the target site in CNS diseases like epilepsy. In the rat, pharmacoresistant epilepsy can be mimicked by inducing status epilepticus by intraperitoneal injection o...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Syvänen, Stina, Luurtsema, Gert, Molthoff, Carla FM, Windhorst, Albert D, Huisman, Marc C, Lammertsma, Adriaan A, Voskuyl, Rob A, de Lange, Elizabeth C
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BioMed Central 2011
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3022839/
https://ncbi.nlm.nih.gov/pubmed/21199574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2342-11-1
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