Alteration in P-glycoprotein Functionality Affects Intrabrain Distribution of Quinidine More Than Brain Entry—A Study in Rats Subjected to Status Epilepticus by Kainate

This study aimed to investigate the use of quinidine microdialysis to study potential changes in brain P-glycoprotein functionality after induction of status epilepticus (SE) by kainate. Rats were infused with 10 or 20 mg/kg quinidine over 30 min or 4 h. Plasma, brain extracellular fluid (brain ECF)...

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Main Authors: Syvänen, Stina, Schenke, Maarten, van den Berg, Dirk-Jan, Voskuyl, Rob A., de Lange, Elizabeth C.
Format: Artigo
Jezik:Inglês
Izdano: Springer US 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3281999/
https://ncbi.nlm.nih.gov/pubmed/22215264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-011-9318-1
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