Sphingosine Kinase-1 Associates with Integrin α(V)β(3) to Mediate Endothelial Cell Survival

Sphingosine kinase (SK)-1 promotes endothelial cell (EC) survival through the cell junction molecule CD31 (platelet endothelial cell adhesion molecule-1). The integrin α(v)β(3) is also essential for EC survival; inhibition of α(v)β(3) ligation promotes apoptosis. Herein we demonstrate that under bas...

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Bibliografiske detaljer
Main Authors: Gamble, Jennifer R., Sun, Wai Y., Li, Xiaochun, Hahn, Christopher N., Pitson, Stuart M., Vadas, Mathew A., Bonder, Claudine S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2009
Fag:
Regular Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2774083/
https://ncbi.nlm.nih.gov/pubmed/19815712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2009.090076
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