Basal and angiopoietin-1–mediated endothelial permeability is regulated by sphingosine kinase-1

Endothelial cells (ECs) regulate the barrier function of blood vessels. Here we show that basal and angiopoietin-1 (Ang-1)–regulated control of EC permeability is mediated by 2 different functional states of sphingosine kinase-1 (SK-1). Mice depleted of SK-1 have increased vascular leakiness, wherea...

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Detalhes bibliográficos
Main Authors: Li, Xiaochun, Stankovic, Milena, Bonder, Claudine S., Hahn, Christopher N., Parsons, Michelle, Pitson, Stuart M., Xia, Pu, Proia, Richard L., Vadas, Mathew A., Gamble, Jennifer R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2008
Assuntos:
Hemostasis, Thrombosis, and Vascular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2275017/
https://ncbi.nlm.nih.gov/pubmed/18199826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-05-092148
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