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Basal and angiopoietin-1–mediated endothelial permeability is regulated by sphingosine kinase-1
Endothelial cells (ECs) regulate the barrier function of blood vessels. Here we show that basal and angiopoietin-1 (Ang-1)–regulated control of EC permeability is mediated by 2 different functional states of sphingosine kinase-1 (SK-1). Mice depleted of SK-1 have increased vascular leakiness, wherea...
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| Главные авторы: | , , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society of Hematology
2008
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2275017/ https://ncbi.nlm.nih.gov/pubmed/18199826 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-05-092148 |
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