Presenilins Are Enriched in Endoplasmic Reticulum Membranes Associated with Mitochondria

Presenilin-1 (PS1) and -2 (PS2), which when mutated cause familial Alzheimer disease, have been localized to numerous compartments of the cell, including the endoplasmic reticulum, Golgi, nuclear envelope, endosomes, lysosomes, the plasma membrane, and mitochondria. Using three complementary approac...

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Detalhes bibliográficos
Main Authors: Area-Gomez, Estela, de Groof, Ad J.C., Boldogh, Istvan, Bird, Thomas D., Gibson, Gary E., Koehler, Carla M., Yu, Wai Haung, Duff, Karen E., Yaffe, Michael P., Pon, Liza A., Schon, Eric A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2009
Assuntos:
Short Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2774047/
https://ncbi.nlm.nih.gov/pubmed/19834068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2009.090219
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