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HPV E6 protein interacts physically and functionally with the cellular telomerase complex

Telomerase activation is critical for the immortalization of primary human keratinocytes by the high-risk HPV E6 and E7 oncoproteins, and this activation is mediated in part by E6-induction of the hTERT promoter. E6 induces the hTERT promoter via interactions with the cellular ubiquitin ligase, E6AP...

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Hlavní autoři: Liu, Xuefeng, Dakic, Aleksandra, Zhang, Yiyu, Dai, Yuhai, Chen, Renxiang, Schlegel, Richard
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2773972/
https://ncbi.nlm.nih.gov/pubmed/19843693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0906357106
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