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Human papillomavirus E6 and Myc proteins associate in vivo and bind to and cooperatively activate the telomerase reverse transcriptase promoter

The papillomavirus E6 protein binds and directs the ubiquitin-dependent degradation of the p53 tumor suppressor protein. Independent of this p53-degradative function, however, E6 induces cellular telomerase activity. This increase in enzyme activity reflects E6-enhanced transcription of the human te...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Veldman, Tim, Liu, Xuefeng, Yuan, Hang, Schlegel, Richard
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2003
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC166208/
https://ncbi.nlm.nih.gov/pubmed/12821782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1435900100
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