Relationship Between CD8-Dependent Antigen Recognition, T Cell Functional Avidity, and Tumor Cell Recognition

Effective immunotherapy using T cell receptor (TCR) gene-modified T cells requires an understanding of the relationship between TCR affinity and functional avidity of T cells. In this study, we evaluate the relative affinity of two TCRs isolated from HLA-A2-restricted, gp100-reactive T cell clones w...

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Main Authors: Moore, Tamson V., Lyons, Gretchen E., Brasic, Natasha, Roszkowski, Jeffrey J., Voelkl, Simon, Mackensen, Andreas, Kast, W. Martin, Le Poole, I. Caroline, Nishimura, Michael I.
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2773431/
https://ncbi.nlm.nih.gov/pubmed/18836717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-008-0594-2
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