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Crystallographic Definition of the Epitope Promiscuity of the Broadly Neutralizing Anti-Human Immunodeficiency Virus Type 1 Antibody 2F5: Vaccine Design Implications

The quest to create a human immunodeficiency virus type 1 (HIV-1) vaccine capable of eliciting broadly neutralizing antibodies against Env has been challenging. Among other problems, one difficulty in creating a potent immunogen resides in the substantial overall sequence variability of the HIV enve...

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Detalhes bibliográficos
Main Authors: Bryson, Steve, Julien, Jean-Philippe, Hynes, Rosemary C., Pai, Emil F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2772703/
https://ncbi.nlm.nih.gov/pubmed/19740978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01604-09
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