Genetic Association Analysis of the Functional c.714T>G Polymorphism and Mucosal Expression of Dectin-1 in Inflammatory Bowel Disease

BACKGROUND: Dectin-1 is a pattern recognition receptor (PRR) expressed by myeloid cells that specifically recognizes β-1,3 glucan, a polysaccharide and major component of the fungal cell wall. Upon activation, dectin-1 signaling converges, similar to NOD2, on the adaptor molecule CARD9 which is asso...

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Hauptverfasser: de Vries, Hilbert S., Plantinga, Theo S., van Krieken, J. Han, Stienstra, Rinke, van Bodegraven, Ad A., Festen, Eleonora A. M., Weersma, Rinse K., Crusius, J. Bart A., Linskens, Ronald K., Joosten, Leo A. B., Netea, Mihai G., de Jong, Dirk J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2009
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2771910/
https://ncbi.nlm.nih.gov/pubmed/19915667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007818
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