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Foxp3-deficient regulatory T cells do not revert into conventional effector CD4(+) T cells but constitute a unique cell subset
Homeostasis in the immune system is maintained by specialized regulatory CD4(+) T cells (T(reg)) expressing transcription factor Foxp3. According to the current paradigm, high affinity interactions between T cell receptors (TCRs) and class II MHC/peptide complexes in thymus “instruct” developing thy...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2771373/ https://ncbi.nlm.nih.gov/pubmed/19710455 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0800601 |
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