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Non-self antigens are the cognate specificities of Foxp3(+) regulatory T cells.
The majority of regulatory Foxp3(+)CD4(+) T cells naturally arises in the thymus. It has been proposed that T cell receptors (TCRs) on these cells recognize self MHC class II-peptide complexes with high or higher affinity, and that their specificities mirror specificities of autoreactive T cells. He...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2276657/ https://ncbi.nlm.nih.gov/pubmed/17869133 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2007.07.019 |
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