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Positive Selection of Cd4(+) T Cells Is Induced in Vivo by Agonist and Inhibited by Antagonist Peptides

The nature of peptides that positively select T cells in the thymus remains poorly defined. Here we report an in vivo model to study the mechanisms of positive selection of CD4(+) T cells. We have restored positive selection of TCR transgenic CD4(+) thymocytes, arrested at the CD4(+)CD8(+) stage, du...

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Main Authors: Kraj, Piotr, Pacholczyk, Rafal, Ignatowicz, Hanna, Kisielow, Pawel, Jensen, Peter, Ignatowicz, Leszek
格式: Artigo
語言:Inglês
出版: The Rockefeller University Press 2001
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193504/
https://ncbi.nlm.nih.gov/pubmed/11514598
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