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The same self-peptide selects conventional and regulatory CD4(+) T cells with identical antigen receptors

The role of the T cell receptor (TCR) in commitment of thymocytes to regulatory CD4(+)Foxp3(+) and conventional CD4(−)Foxp3(−) T cell lineages remains controversial. According to the prevailing view, commitment to the former lineage, in contrast to the latter, requires that high affinity TCRs bind r...

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Detalhes bibliográficos
Main Authors: Wojciech, Lukasz, Ignatowicz, Alicja, Seweryn, Michal, Rempala, Grzegorz, Pabla, Simarjot Singh, McIndoe, Richard A., Kisielow, Pawel, Ignatowicz, Leszek
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4183978/
https://ncbi.nlm.nih.gov/pubmed/25270305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6061
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