Anti-GITR Antibody Treatment Increases TCR Repertoire Diversity of Regulatory but not Effector T Cells Engaged in the Immune Response Against B16 Melanoma

Crosslinking of glucocorticoid-induced TNF family-related receptor (GITR) with agonist antibodies restores cancer immunity by enhancing effector T cell (Teff) responses while interfering with intra-tumor regulatory T cell (Treg) stability and/or accumulation. However, how anti-GITR antibody infusion...

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Bibliographische Detailangaben
Veröffentlicht in:Arch Immunol Ther Exp (Warsz)
Hauptverfasser: Scirka, Bozena, Szurek, Edyta, Pietrzak, Maciej, Rempala, Grzegorz, Kisielow, Pawel, Ignatowicz, Leszek, Miazek, Arkadiusz
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer International Publishing 2017
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5688217/
https://ncbi.nlm.nih.gov/pubmed/28638937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00005-017-0479-1
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