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Thymus-derived regulatory T cells control tolerance to commensal microbiota
Peripheral mechanisms preventing autoimmunity and maintaining tolerance to commensal microbiota involve CD4(+)Foxp3(+) regulatory T cells(1,2) generated in the thymus (tTregs) or extrathymically by induction of naive CD4(+)Foxp3(−) T cells (iTregs). Prior studies suggested that the T cell receptor (...
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| Main Authors: | , , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2013
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3711137/ https://ncbi.nlm.nih.gov/pubmed/23624374 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12079 |
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