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De novo Synthesis of Modified Saxitoxins for Sodium Ion Channel Study

[Image: see text] Access to novel forms of (+)-saxitoxin (STX), a potent and selective inhibitor of voltage-gated Na(+) ion channels, has been made possible through de novo synthesis. Saxitoxin is believed to lodge in the outer mouth of the channel pore, thereby stoppering ion flux. Herein, we demon...

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Bibliographic Details
Main Authors: Andresen, Brian M., Bois, J. Du
Format: Artigo
Language:Inglês
Published: 2009
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2770901/
https://ncbi.nlm.nih.gov/pubmed/19678702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja904179f
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