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Inhibition of Sodium Ion Channel Function with Truncated Forms of Batrachotoxin
A novel family of small molecule inhibitors of voltage-gated sodium channels (Na(v)s) based on the structure of batrachotoxin (BTX) – a well-known channel agonist – is described. Protein mutagenesis and electrophysiology experiments reveal the binding site as the inner pore region of the channel, an...
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| Publicado en: | ACS Chem Neurosci |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2016
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5555364/ https://ncbi.nlm.nih.gov/pubmed/27501251 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.6b00212 |
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