KEAP1 E3 Ligase-Mediated Down-Regulation of NF-κB Signaling by Targeting IKKβ

IκB kinase β (IKKβ) is involved in tumor development and progression through activation of the nuclear factor (NF)–κB pathway. However, the molecular mechanism that regulates IKKβ degradation remains largely unknown. Here, we show that a Cullin 3 (CUL3)–based ubiquitin ligase, Kelch-like ECH-associa...

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Bibliografiska uppgifter
Huvudupphovsmän: Lee, Dung-Fang, Kuo, Hsu-Ping, Liu, Mo, Chou, Chao-Kai, Xia, Weiya, Du, Yi, Shen, Jia, Chen, Chun-Te, Huo, Longfei, Hsu, Ming-Chuan, Li, Chia-Wei, Ding, Qingqing, Liao, Tsai-Lien, Lai, Chien-Chen, Lin, Ann-Chi, Chang, Ya-Hui, Tsai, Shih-Feng, Li, Long-Yuan, Hung, Mien-Chie
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2009
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2770835/
https://ncbi.nlm.nih.gov/pubmed/19818716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.07.025
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