KEAP1 E3 Ligase-Mediated Down-Regulation of NF-κB Signaling by Targeting IKKβ

IκB kinase β (IKKβ) is involved in tumor development and progression through activation of the nuclear factor (NF)–κB pathway. However, the molecular mechanism that regulates IKKβ degradation remains largely unknown. Here, we show that a Cullin 3 (CUL3)–based ubiquitin ligase, Kelch-like ECH-associa...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Lee, Dung-Fang, Kuo, Hsu-Ping, Liu, Mo, Chou, Chao-Kai, Xia, Weiya, Du, Yi, Shen, Jia, Chen, Chun-Te, Huo, Longfei, Hsu, Ming-Chuan, Li, Chia-Wei, Ding, Qingqing, Liao, Tsai-Lien, Lai, Chien-Chen, Lin, Ann-Chi, Chang, Ya-Hui, Tsai, Shih-Feng, Li, Long-Yuan, Hung, Mien-Chie
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2770835/
https://ncbi.nlm.nih.gov/pubmed/19818716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.07.025
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi