Hyperosmolarity regulates SOX9 mRNA posttranscriptionally in human articular chondrocytes

The transcription factor SOX9 regulates cartilage extracellular matrix gene expression and is essential for chondrocyte differentiation. We previously showed that activation of p38 MAPK by cycloheximide in human chondrocytes leads to stabilization of SOX9 mRNA (Tew SR and Hardingham TE. J Biol Chem...

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Main Authors: Tew, Simon R., Peffers, Mandy J., McKay, Tristan R., Lowe, Emma T., Khan, Wasim S., Hardingham, Timothy E., Clegg, Peter D.
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2009
Fag:
Receptors and Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2770738/
https://ncbi.nlm.nih.gov/pubmed/19657054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00571.2008
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