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CpG methylation potentiates pixantrone and doxorubicin-induced DNA damage and is a marker of drug sensitivity
DNA methylation is an epigenetic modification of the mammalian genome that occurs predominantly at cytosine residues of the CpG dinucleotide. Following formaldehyde activation, pixantrone alkylates DNA and particularly favours the CpG motif. Aberrations in CpG methylation patterns are a feature of m...
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| Main Authors: | , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Oxford University Press
2009
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2770666/ https://ncbi.nlm.nih.gov/pubmed/19720735 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp700 |
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