CpG methylation potentiates pixantrone and doxorubicin-induced DNA damage and is a marker of drug sensitivity

DNA methylation is an epigenetic modification of the mammalian genome that occurs predominantly at cytosine residues of the CpG dinucleotide. Following formaldehyde activation, pixantrone alkylates DNA and particularly favours the CpG motif. Aberrations in CpG methylation patterns are a feature of m...

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Detalhes bibliográficos
Main Authors: Evison, Benny J., Bilardi, Rebecca A., Chiu, Francis C. K., Pezzoni, Gabriella, Phillips, Don R., Cutts, Suzanne M.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2009
Assuntos:
Gene Regulation, Chromatin and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2770666/
https://ncbi.nlm.nih.gov/pubmed/19720735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp700
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