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Pixantrone can be activated by formaldehyde to generate a potent DNA adduct forming agent
Mitoxantrone is an anti-cancer agent used in the treatment of breast and prostate cancers. It is classified as a topoisomerase II poison, however can also be activated by formaldehyde to generate drug–DNA adducts. Despite identification of this novel form of mitoxantrone–DNA interaction, excessively...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Oxford University Press
2007
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1920253/ https://ncbi.nlm.nih.gov/pubmed/17483512 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm285 |
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