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Discovery of diarylpyridine derivatives as novel non-nucleoside HIV-1 reverse transcriptase inhibitors
Two series (4 and 5) of diarylpyridine derivatives were designed, synthesized, and evaluated for anti-HIV-1 activity. The most promising compound, 5e, inhibited HIV-1 IIIB, NL4-3, and RTMDR1 with low nanomolar EC(50) values and selectivity indexes of >10,000. The results of this study indicate th...
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| Hlavní autoři: | , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2009
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2770631/ https://ncbi.nlm.nih.gov/pubmed/19666220 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.07.080 |
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