Rational Design Leads to More Potent RNA Interference Against Hepatitis B Virus: Factors Effecting Silencing Efficiency

RNA interference (RNAi) can be an effective antiviral agent; however, overexpression of RNAi can be toxic through competition with the endogenous microRNA (miRNA) machinery. We used rational design to identify highly potent RNAi that is effective at nontoxic doses. A statistical analysis was conduct...

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Detalhes bibliográficos
Main Authors: Keck, Kathy, Volper, Esther M, Spengler, Ryan M, Long, Dang D, Chan, Chi Y, Ding, Ye, McCaffrey, Anton P
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2008
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2770508/
https://ncbi.nlm.nih.gov/pubmed/19088704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2008.273
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