Agonist-Biased Signaling via Proteinase Activated Receptor-2: Differential Activation of Calcium and Mitogen-Activated Protein Kinase Pathways

We evaluated the ability of different trypsin-revealed tethered ligand (TL) sequences of rat proteinase-activated receptor 2 (rPAR(2)) and the corresponding soluble TL-derived agonist peptides to trigger agonist-biased signaling. To do so, we mutated the proteolytically revealed TL sequence of rPAR(...

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Hlavní autoři: Ramachandran, Rithwik, Mihara, Koichiro, Mathur, Maneesh, Rochdi, Moulay Driss, Bouvier, Michel, DeFea, Kathryn, Hollenberg, Morley D.
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2769049/
https://ncbi.nlm.nih.gov/pubmed/19605524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.109.055509
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