Potent Inhibition of HIV-1 Replication by a Tat Mutant

Herein we describe a mutant of the two-exon HIV-1 Tat protein, termed Nullbasic, that potently inhibits multiple steps of the HIV-1 replication cycle. Nullbasic was created by replacing the entire arginine-rich basic domain of wild type Tat with glycine/alanine residues. Like similarly mutated one-e...

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Bibliographic Details
Main Authors: Meredith, Luke W., Sivakumaran, Haran, Major, Lee, Suhrbier, Andreas, Harrich, David
Format: Artigo
Language:Inglês
Published: Public Library of Science 2009
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2768900/
https://ncbi.nlm.nih.gov/pubmed/19901984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007769
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