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Potent Inhibition of HIV-1 Replication by a Tat Mutant
Herein we describe a mutant of the two-exon HIV-1 Tat protein, termed Nullbasic, that potently inhibits multiple steps of the HIV-1 replication cycle. Nullbasic was created by replacing the entire arginine-rich basic domain of wild type Tat with glycine/alanine residues. Like similarly mutated one-e...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Public Library of Science
2009
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2768900/ https://ncbi.nlm.nih.gov/pubmed/19901984 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007769 |
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