Inducible Costimulator Expression Regulates the Magnitude of Th2-Mediated Airway Inflammation by Regulating the Number of Th2 Cells

BACKGROUND: Inducible Costimulator (ICOS) is an important regulator of Th2 lymphocyte function and a potential immunotherapeutic target for allergy and asthma. A SNP in the ICOS 5′ promoter in humans is associated with increased atopy and serum IgE in a founder population and increased ICOS surface...

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Main Authors: Clay, Bryan S., Shilling, Rebecca A., Bandukwala, Hozefa S., Moore, Tamson V., Cannon, Judy L., Welcher, Andrew A., Weinstock, Joel V., Sperling, Anne I.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2009
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2768787/
https://ncbi.nlm.nih.gov/pubmed/19888475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007525
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