CD28 and ICOS play complementary non-overlapping roles in the development of Th2 immunity in vivo

Previous work has shown ICOS can function independently of CD28, but whether either molecule can compensate for the other in vivo is not known. Since ICOS is a potent inducer of Th2 cytokines and linked to allergy and elevated serum IgE in humans, we hypothesized that augmenting ICOS costimulation i...

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Autori principali: Shilling, Rebecca A., Clay, Bryan S., Tesciuba, Amanda G., Berry, Elizabeth L., Lu, Tiffany, Moore, Tamson V., Bandukwala, Hozefa S., Tong, Jiankun, Weinstock, Joel V., Flavell, Richard A., Horan, Tom, Yoshinaga, Steve K., Welcher, Andrew A., Cannon, Judy L., Sperling, Anne I.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2748173/
https://ncbi.nlm.nih.gov/pubmed/19646680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellimm.2009.06.013
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