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THE ROLE OF THE mTOR NUTRIENT SIGNALING PATHWAY IN CHONDROCYTE DIFFERENTIATION

The mammalian Target of Rapamycin (mTOR) is a nutrient-sensing protein kinase that regulates numerous cellular processes. Physilogical fetal rat metatarsal explant cultures were used, to study the effect of mTOR inhibition on chondrogenesis. Insulin significantly enhanced bone growth. Rapamycin sign...

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Bibliografische gegevens
Hoofdauteurs: Phornphutkul, Chanika, Wu, Ke-Ying, Auyeung, Valerie, Chen, Qian, Gruppuso, Philip A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2008
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2768549/
https://ncbi.nlm.nih.gov/pubmed/18265001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/dvdy.21464
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