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An autonomous CDR3δ is sufficient for γδ T cell recognition of the nonclassical MHC-I T10/T22
It remains unclear whether γδ T cell receptors (TCRs) detect antigens in a manner similar to antibodies or αβ TCRs. Here we show that reactivity between G8 and KN6 γδ TCRs and the MHC class Ib molecule T22 can be transplanted, with retention of wild-type ligand affinity, after en bloc grafting of G8...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2768525/ https://ncbi.nlm.nih.gov/pubmed/18516039 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1620 |
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