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An autonomous CDR3δ is sufficient for γδ T cell recognition of the nonclassical MHC-I T10/T22

It remains unclear whether γδ T cell receptors (TCRs) detect antigens in a manner similar to antibodies or αβ TCRs. Here we show that reactivity between G8 and KN6 γδ TCRs and the MHC class Ib molecule T22 can be transplanted, with retention of wild-type ligand affinity, after en bloc grafting of G8...

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Detalles Bibliográficos
Main Authors: Adams, Erin J, Strop, Pavel, Shin, Sunny, Chien, Yueh-Hsiu, Garcia, K Christopher
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2768525/
https://ncbi.nlm.nih.gov/pubmed/18516039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1620
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