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P2X7 receptor-stimulated secretion of MHC-II-containing exosomes requires the ASC/NLRP3 inflammasome but is independent of caspase-1

We recently reported that P2X7 receptor (P2X7R)-induced activation of caspase-1 inflammasomes is accompanied by release of MHC-II protein into extracellular compartments during brief stimulation of murine macrophages with ATP. Here we demonstrate that MHC-II containing membranes released from macrop...

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Detalhes bibliográficos
Main Authors: Qu, Yan, Ramachandra, Lakshmi, Mohr, Susanne, Franchi, Luigi, Harding, Clifford V., Nunez, Gabriel, Dubyak, George R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2768485/
https://ncbi.nlm.nih.gov/pubmed/19342685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0802968
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