The Synergistic Effect of Conditional Pten Loss and Oncogenic K-ras Mutation on Endometrial Cancer Development Occurs via Decreased Progesterone Receptor Action

Endometrial cancer is the most common gynecological cancer. Estrogen-dependent endometrioid carcinoma is the most common type of endometrial cancer, and alterations in the expression of PTEN and K-ras have been associated with this disease. To study the roles of Pten and K-ras in endometrial cancer,...

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Main Authors: Kim, Tae Hoon, Wang, Jinrong, Lee, Kevin Y., Franco, Heather L., Broaddus, Russell R., Lydon, John P., Jeong, Jae-Wook, DeMayo, Francesco J.
Format: Artigo
Sprog:Inglês
Udgivet: Hindawi Publishing Corporation 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2768008/
https://ncbi.nlm.nih.gov/pubmed/19884980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2010/139087
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