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Clinically Relevant Effects of Convection-Enhanced Delivery of AAV2-GDNF on the Dopaminergic Nigrostriatal Pathway in Aged Rhesus Monkeys

Growth factor therapy for Parkinson's disease offers the prospect of restoration of dopaminergic innervation and/or prevention of neurodegeneration. Safety and efficacy of an adeno-associated virus (AAV2) encoding human glial cell-derived neurotrophic factor (GDNF) was investigated in aged nonh...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Johnston, Louisa C., Eberling, Jamie, Pivirotto, Philip, Hadaczek, Piotr, Federoff, Howard J., Forsayeth, John, Bankiewicz, Krystof S.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Mary Ann Liebert, Inc. 2009
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2767387/
https://ncbi.nlm.nih.gov/pubmed/19203243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2008.137
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