Structural Insights of Glucan Phosphatase Dynamics using Amide Hydrogen/Deuterium Exchange Mass Spectrometry

Laforin and Starch Excess 4 (SEX4) are founding members of a class of phosphatases that dephosphorylate phosphoglucans. Each protein contains a carbohydrate binding module (CBM) and a dual specificity phosphatase (DSP) domain. The gene encoding laforin is mutated in a fatal neurodegenerative disease...

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Main Authors: Hsu, Simon, Kim, Youngjun, Li, Sheng, Durrant, Eric S., Pace, Rachel M., Woods, Virgil L., Gentry, Matthew S.
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2767375/
https://ncbi.nlm.nih.gov/pubmed/19754155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi9008853
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